No effect of bicarbonate treatment on insulin sensitivity and glucose control in non-diabetic older adults
Identifieur interne : 003052 ( Main/Exploration ); précédent : 003051; suivant : 003053No effect of bicarbonate treatment on insulin sensitivity and glucose control in non-diabetic older adults
Auteurs : Susan S. Harris [États-Unis] ; Bess Dawson-Hughes [États-Unis]Source :
- Endocrine [ 1355-008X ] ; 2010-10-01.
English descriptors
Abstract
Abstract: Chronic mild metabolic acidosis is common among older adults, and limited evidence suggests that it may contribute to insulin resistance and type-2 diabetes. This analysis was conducted to determine whether bicarbonate supplementation, an alkalinizing treatment, improves insulin sensitivity or glucose control in non-diabetic older adults. Fasting blood glucose and insulin were measured in stored samples from subjects who had completed a 3-month clinical trial of bicarbonate supplementation to improve indicators of bone and muscle health. One hundred and fifty three ambulatory, non-diabetic adults aged 50 years and older were studied. Subjects were randomized to one of two bicarbonate groups (67.5 mmol/day of potassium bicarbonate or sodium bicarbonate) or to one of two no-bicarbonate groups (67.5 mmol/day of placebo or potassium chloride). Subjects remained on treatment throughout the 3-month study. The primary outcome measures were changes in fasting plasma glucose, serum insulin and HOMA-IR, an index of insulin resistance. Bicarbonate supplementation reduced net acid excretion (adjusted mean ± SEM for the change in NAE/creatinine, mmol/mmol, was 0.23 ± 0.22 in the no-bicarbonate group compared with −3.53 ± 0.22 in the bicarbonate group, P < 0.001) but had no effect on fasting plasma glucose, serum insulin, or HOMA-IR. In conclusion, bicarbonate supplementation does not appear to improve insulin sensitivity or glucose control in non-diabetic older adults.
Url:
DOI: 10.1007/s12020-010-9377-6
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001C70
- to stream Istex, to step Curation: 001C49
- to stream Istex, to step Checkpoint: 000814
- to stream Main, to step Merge: 003109
- to stream Main, to step Curation: 003052
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">No effect of bicarbonate treatment on insulin sensitivity and glucose control in non-diabetic older adults</title><author><name sortKey="Harris, Susan S" sort="Harris, Susan S" uniqKey="Harris S" first="Susan S." last="Harris">Susan S. Harris</name></author><author><name sortKey="Dawson Hughes, Bess" sort="Dawson Hughes, Bess" uniqKey="Dawson Hughes B" first="Bess" last="Dawson-Hughes">Bess Dawson-Hughes</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:7B6D8B1BEAE44A11BF716CA573CB9A083C2BAE4D</idno><date when="2010" year="2010">2010</date><idno type="doi">10.1007/s12020-010-9377-6</idno><idno type="url">https://api.istex.fr/ark:/67375/VQC-4K6X99CX-S/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">001C70</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001C70</idno><idno type="wicri:Area/Istex/Curation">001C49</idno><idno type="wicri:Area/Istex/Checkpoint">000814</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000814</idno><idno type="wicri:doubleKey">1355-008X:2010:Harris S:no:effect:of</idno><idno type="wicri:Area/Main/Merge">003109</idno><idno type="wicri:Area/Main/Curation">003052</idno><idno type="wicri:Area/Main/Exploration">003052</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">No effect of bicarbonate treatment on insulin sensitivity and glucose control in non-diabetic older adults</title><author><name sortKey="Harris, Susan S" sort="Harris, Susan S" uniqKey="Harris S" first="Susan S." last="Harris">Susan S. Harris</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington St., 02111, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">États-Unis</country></affiliation></author><author><name sortKey="Dawson Hughes, Bess" sort="Dawson Hughes, Bess" uniqKey="Dawson Hughes B" first="Bess" last="Dawson-Hughes">Bess Dawson-Hughes</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington St., 02111, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Endocrine</title><title level="j" type="abbrev">Endocr</title><idno type="ISSN">1355-008X</idno><idno type="eISSN">1559-0100</idno><imprint><publisher>Springer US; http://www.springer-ny.com</publisher><pubPlace>Boston</pubPlace><date type="published" when="2010-10-01">2010-10-01</date><biblScope unit="volume">38</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="221">221</biblScope><biblScope unit="page" to="226">226</biblScope></imprint><idno type="ISSN">1355-008X</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1355-008X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Bicarbonate</term><term>Glucose control</term><term>Insulin resistance</term><term>Metabolic acidosis</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Chronic mild metabolic acidosis is common among older adults, and limited evidence suggests that it may contribute to insulin resistance and type-2 diabetes. This analysis was conducted to determine whether bicarbonate supplementation, an alkalinizing treatment, improves insulin sensitivity or glucose control in non-diabetic older adults. Fasting blood glucose and insulin were measured in stored samples from subjects who had completed a 3-month clinical trial of bicarbonate supplementation to improve indicators of bone and muscle health. One hundred and fifty three ambulatory, non-diabetic adults aged 50 years and older were studied. Subjects were randomized to one of two bicarbonate groups (67.5 mmol/day of potassium bicarbonate or sodium bicarbonate) or to one of two no-bicarbonate groups (67.5 mmol/day of placebo or potassium chloride). Subjects remained on treatment throughout the 3-month study. The primary outcome measures were changes in fasting plasma glucose, serum insulin and HOMA-IR, an index of insulin resistance. Bicarbonate supplementation reduced net acid excretion (adjusted mean ± SEM for the change in NAE/creatinine, mmol/mmol, was 0.23 ± 0.22 in the no-bicarbonate group compared with −3.53 ± 0.22 in the bicarbonate group, P < 0.001) but had no effect on fasting plasma glucose, serum insulin, or HOMA-IR. In conclusion, bicarbonate supplementation does not appear to improve insulin sensitivity or glucose control in non-diabetic older adults.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Massachusetts</li></region></list><tree><country name="États-Unis"><region name="Massachusetts"><name sortKey="Harris, Susan S" sort="Harris, Susan S" uniqKey="Harris S" first="Susan S." last="Harris">Susan S. Harris</name></region><name sortKey="Dawson Hughes, Bess" sort="Dawson Hughes, Bess" uniqKey="Dawson Hughes B" first="Bess" last="Dawson-Hughes">Bess Dawson-Hughes</name><name sortKey="Harris, Susan S" sort="Harris, Susan S" uniqKey="Harris S" first="Susan S." last="Harris">Susan S. Harris</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Lorraine/explor/InforLorV4/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003052 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003052 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Lorraine
|area= InforLorV4
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:7B6D8B1BEAE44A11BF716CA573CB9A083C2BAE4D
|texte= No effect of bicarbonate treatment on insulin sensitivity and glucose control in non-diabetic older adults
}}
| This area was generated with Dilib version V0.6.33. |  |